Extracellular Matrix (ECM) technology is the scaffold on which new tissue growth is constructed. It is the structure that makes new tissues regeneration possible. MatriStem the only commercially available ECM made of urinary bladder matrix (UBM).
Urinary Bladder Matrix (UBM) is derived from porcine urinary bladder. The bladder is harvested and processed to remove the muscle and submucosa tissue layers. The UBM is disinfected, packaged, and sterilized. The resulting product is a non-crosslinked, completely resorbable, acellular extracellular matrix scaffold, rich with naturally-occurring collagens and proteins and maintains an intact epithelial basement membrane surface.
This ECM scaffold technology is recognized by its bimodal surface characteristics. The intact basement membrane surface is hypothesized to contribute to epithelial and progenitor cell attachment and proliferation. The lamina propria surface may be conducive for integration into the wound bed and host connective tissues.
UBM has been researched extensively and its characteristics have been shown to be beneficial for various wound and surgical applications.
Characteristics of UBM
UBM contains a collection of collagens and proteins arranged in a three-dimensional structure not currently available in synthetic materials and has been demonstrated to:
- Maintain an intact epithelial basement membrane1
- Contain numerous collagens1
- Contain laminin1
- Contain numerous growth factors2
- Display antimicrobial activity3
- Contain glycosaminoglycans (GAGs)4
- Incorporate completely5
UBM appears to fundamentally change the healing response by providing signals to the host immune system that stimulate an adaptive or accommodative response, conducive for wound healing and three-dimensional growth of various cell types.6 UBM has been shown to:
- Recruit progenitor cells7
- Demonstrate chemotactic and mitogenic activities8
- Constructively remodel site-specific tissues where scarring would be expected5
- Brown B, Lindberg K, Reing J, et al. The basement membrane component of biologic scaffolds derived from extracellular matrix. Tissue Eng. 2006 Mar; 12(3):519-26.
- Growth factor data on file.
- Brennan EP, Reing J, Chew D, et al. Antibacterial activity within degradation products of biological scaffolds composed of extracellular matrix. Tissue Eng. 2006 Oct; 12(10):2949-55.
- GAG data on file.
- Gilbert TW, Nieponice A, Spievack AR, et al. Repair of the Thoracic Wall With an Extracellular Matrix Scaffold in a Canine Model. J Surg Res. 2007 Oct 18.
- Brown BN, Valentin JE, Stewart-Akers AM, et al. Macrophage phenotype and remodeling outcomes in response to biologic scaffolds with and without a cellular component. Biomaterials. 2009 Mar;30(8):1482-91.
- Beattie A, Gilbert TW, Guyot J, et al. Chemoattraction of Progenitor Cells by Remodeling Extracellular Matrix Scaffolds. Tissue Eng. Part A. May 2009, 15(5): 1119-1125.
- Reing JE, Zhang L, Myers-Irvin J, et al. Degradation products of extracellular matrix affect cell migration and proliferation. Tissue Eng Part A. 2009 Mar;15(3):605-14.