MatriStem devices are comprised of naturally-occurring porcine urinary bladder matrix (UBM). The bladder is harvested and processed to remove the muscle and submucosa tissue layers. The product is disinfected, packaged, and sterilized via electron beam radiation. The resulting product is a non-crosslinked, completely resorbable, acellular extracellular matrix scaffold with naturally-occurring collagens, featuring an intact epithelial basement membrane surface and tunica propria surface.
MatriStem contains a collection of proteins arranged in a three-dimensional structure not currently available in synthetic materials. This ECM scaffold technology is recognized by its bimodal surface characteristics. The intact basement membrane surface is hypothesized to contribute to epithelial and progenitor cell attachment and proliferation. The lamina propria surface may be conducive for integration into the wound bed and host connective tissues.
The product completely incorporates into the surrounding tissue during the healing process and leaves new tissue where scar tissue formation is normally expected. The result is constructively remodeled, site-specific tissue for a variety of medical procedures.
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