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About Us - Scientific Overview
ACell’s MatriStem® technology is a naturally occurring, non-crosslinked, completely resorbable, acellular material. MatriStem devices are unique from other scaffold technologies in that they fundamentally change healing by triggering abundant new blood vessel formation and recruiting numerous cell types to the site of injury. It appears that these cells, including progenitor cells, have the potential to differentiate into numerous types of site specific tissues. During the healing process, the scaffold is degraded and completely resorbed, leaving new tissue where scar tissue would normally be expected. This proprietary UBM scaffold technology can be used in a broad range of medical applications such as wound care, general surgery, gastrointestinal surgery, urology and plastic and reconstructive surgery.
The ACell MatriStem bioscaffold appears to provide signals to the host immune system that stimulate an adaptive or accommodative response that is ideal for both wound healing and three-dimensional growth of various cell types. The ACell MatriStem bioscaffold is distinguished from other ECM scaffold technology by its unique bimodal surface characteristics. One surface consists of an intact basement membrane which is especially conducive to epithelial and endothelial cell attachment, proliferation, and differentiation (a key advantage in applications such dermatology, plastic and reconstructive surgery, and urology). The opposite surface consists of organized connective tissue comprised of the urinary bladder lamina propria. This surface is ideal for integration into wound bed and host connective tissues, and supports vascular ingrowth. MatriStem devices consist of a collection of both structural and functional proteins (such as Laminin, Collagen type IV and VII) that are arranged in a three-dimensional ultrastructure that is virtually impossible to reproduce in the laboratory. Growth factors native to the tissue layers comprising MatriStem devices, such as vascular endothelial growth factor (VEGF), transforming growth factor beta (TGFβ), platelet derived growth factor (PDGF), bone morphogenic protein 4 (BMP4), and basic fibroblast growth factor (BFGF), are present as the matrix resorbs, and support the growth of new blood vessels and the proliferation of connective tissue cells to facilitate the healing and tissue remodeling process.
THE IDEAL BIOMATERIAL
Helps Healing
The MatriStem bioscaffold is a naturally occurring, non-crosslinked, acellular matrix that fundamentally changes the healing response, resulting in a remodeled, functional, site specific tissue. MatriStem devices promote rapid angiogenesis and localized cell growth.
Versatile Bioscaffold
MatriStem devices have demonstrated the ability to remodel into site specific tissue, as complex as esophagus or myocardium. The material’s bimodal surface characteristics are ideal for certain types of tissue healing, particularly where epithelial cells are present.
May Reduce Scar Tissue Formation
Unlike many other biomaterials, rapid degradation and resorption of the MatriStem matrix leaves new tissue where scar tissue formation or adhesions are normally expected.
Excellent Strength and Surgical Handling
MatriStem devices exhibit strong mechanical properties in various configurations depending on the application. The material is easy to handle and has excellent suture retention strength in the repair of soft tissue.
May Resist Infection
It has been shown that antimicrobial activity coincides with the resorption of MatriStem devices, and that naturally occurring biomaterials are more resistant to bacterial infection than synthetic biomaterials.
