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Our Technology

A Platform Technology Unlike Any Other

ACell’s propriety MatriStem UBM™ (Urinary Bladder Matrix) technology is the core of our company’s business. This technology is used in the manufacturing of our Gentrix, Cytal, and MicroMatrix product lines and is the only commercially available form of UBM.

MatriStem UBM technology is based on the research of ACell’s founder, the late Alan Spievack, MD. Dr. Spievack, inspired by the regenerative capabilities of salamanders, studied cell regeneration and extracellular matrices (ECMs), ultimately leading to the development of MatriStem UBM technology.

Characteristics of UBM Devices

ACell’s non-synthetic, fully-resorbable devices are minimally processed to remove cellular content and mitigate the inflammatory response1,8. This propriety manufacturing process preserves the integrity of essential structures and molecular components. The resulting devices contain a collection of collagens and other proteins including growth factors10, laminin, and proteoglycans11, which aid in healing. The devices are characterized by their bimodal structure, which includes:

A Intact Epithelial Basement Membrane: A thin, dense structure ideal for epithelial and progenitor cell attachment and proliferation 1,8

A

B A rough, porous structure ideal for cellular infiltration and neovascularization

B

The molecular components of the device are arranged in a natural, three-dimensional structure with an intact epithelial basement membrane and a lamina propria opposing surface. These product layers act as a bimodal scaffold for cellular infiltration and capillary ingrowth.

What are Macrophages and Why do they Matter?

Macrophages are recognized as primary regulators of wound healing and have two main phenotypes, M1 and M2.

A higher M2:M1 ratio has been associated with site-appropriate tissue remodeling, whereas a higher M1 response is associated with scar tissue formation and/or tissue integration response.

Cellular Responses to UBM

After a MatriStem UBM device is placed in the body, white blood cells including macrophages and neutrophils will enter the UBM scaffold to initiate the remodeling response. Fibroblasts will also enter the scaffold, depositing various collagens that provide strength and structure for the new tissue, and new blood vessels will form transporting blood and nutrients to the site of repair1.

UBM provides an environment where the body is more likely exhibit a higher ratio of M2 to M1 macrophages, which has been shown to facilitate the remodeling of site-appropriate tissue. Instead of scarring, healthy tissue will form that mimics the structure and biomechanical functionality of the surrounding anatomy1. Over time, the devices will fully resorb and completely remodel into the host tissue, leaving no foreign body.

MatriStem UBM Products

Cytal® Wound Matrix

Cytal wound matrix is the sheet form of MatriStem UBM technology indicated for wounds. It is available in a variety of sizes and thicknesses.

MicroMatrix®

MicroMatrix is the particulate form of MatriStem UBM technology indicated for wounds. It is available in regular and fine configurations.

Gentrix Surgical Matrix®

Gentrix surgical matrix is MatriStem UBM technology indicated for soft tissue reinforcement. It is available in a variety of sizes and thicknesses.

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ACell Inc.
6640 Eli Whitney Drive
Columbia, MD 21046
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